Divergent total synthesis of the natural antimalarial marinoquinolines A, B, C, E and unnatural analogues

TETRAHEDRON LETTERS

卷:53

Article

Schwalm, Cristiane Storck¹  Correia, Carlos Roque D.¹ 

[1] Univ Estadual Campinas, UNICAMP, Inst Quim, BR-13084917 Campinas, SP, Brazil

关键词: Marinoquinolines;    Antimalarial;    Heck-Matsuda reactions;    Pictet-Spengler;   

DOI  :  10.1016/j.tetlet.2012.06.115

来源: Elsevier

【 摘 要 】

A new synthetic route to marinoquinolines was developed, allowing the synthesis of several structurally related compounds from a common key intermediate. Four natural marinoquinolines (A, B. C and E) and nine unnatural new analogues were prepared by this strategy, which features a Heck-Matsuda reaction in pure water and the Pictet-Spengler reaction as key steps. (C) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

Free