Synthesis and anticancer activities of ageladine A and structural analogs

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:20

Article

Ma, Yuelong¹  Nam, Sangkil¹  Jove, Richard¹  Yakushijin, Kenichi¹  Horne, David A.¹ 

[1] Beckman Res Inst City Hope, Dept Mol Med, Duarte, CA 91010 USA

关键词: Anticancer;    Ageladine A;    2-Aminoimidazole;    Oroidin;    Pictet-Spengler;   

DOI  :  10.1016/j.bmcl.2009.11.036

来源: Elsevier

【 摘 要 】

A series of ageladine A analogs that include 2-aminoimidazo[4,5-c]azepines (seven-membered rings) and 2-amino-3H-imidazo[4,5-c]pyridine (six-membered rings) derivatives were synthesized and evaluated for their anticancer effects against several human cancer cell lines and MMP-2 inhibition in vitro. Only compounds possessing the aromatic azepine (seven-membered ring) core showed anticancer activity with IC50 values in the low micromolar range. (C) 2009 Elsevier Ltd. All rights reserved.

【 授权许可】

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