Efficient and selective hydration of nitriles to amides in aqueous systems with Ru(II)-phosphaurotropine catalysts

TETRAHEDRON LETTERS

卷:55

Article

Bolyog-Nagy, Evelin¹  Udvardy, Antal¹  Joo, Ferenc^1,2  Katho, Agnes¹ 

[1] Univ Debrecen, Dept Phys Chem, H-4032 Debrecen, Hungary

[2] MTA DE, Homogeneous Catalysis & React Mech Res Grp, H-4032 Debrecen, Hungary

关键词: Nitrile hydration;    Ruthenium;    Phosphine;    Amides;   

DOI  :  10.1016/j.tetlet.2014.04.118

来源: Elsevier

【 摘 要 】

A simple and efficient synthesis of amides by selective hydration of aromatic and aliphatic nitriles is described. The catalysts are prepared in situ from easily available Ru-precursors and ligands using water as the solvent. The most active catalyst, is obtained from [RuCl2(dmso)(4)] and benzylated 1,3,5-triaza-7-phosphaadamantane. Of the 16 substrates examined, 92-99% conversions of 14 nitriles were achieved in one hour at reflux temperature. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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