Biocatalyzed synthesis of both enantiopure fluoromisonidazole antipodes

TETRAHEDRON LETTERS

卷:54

Article

Borzecka, Wioleta¹  Lavandera, Ivan¹  Gotor, Vicente¹ 

[1] Univ Oviedo, Dept Organ & Inorgan Chem, E-33006 Oviedo, Spain

关键词: Fluoromisonidazole;    Fluorohydrins;    Microwave-assisted synthesis;    Biocatalysis;    Alcohol dehydrogenases;   

DOI  :  10.1016/j.tetlet.2013.07.013

来源: Elsevier

【 摘 要 】

Fluoromisonidazole (FMISO or F-MISO) is a radiotracer for positron emission tomography when F-18-labeled and is administrated in its racemic form. Herein, a straightforward synthesis of both enantiopure antipodes is proposed through a one-pot two-step microwave protocol to obtain a fluorinated ketone precursor followed by bioreduction using alcohol dehydrogenases from Rhodococcus ruber (ADH-A) or Lactobacillus brevis (LBADH). (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

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