Microwave-assisted one-step rapid synthesis of dicyano imidazoles by HNO3 as a high efficient promoter

Green Chemistry Letters and Reviews

Mehdi Kalhor¹  Seyed Ahmad Mirshokraei¹  Sima Samiei¹ 

[1] Department of Chemistry, Payame Noor University, Tehran, Ira;

关键词: Microwave-assisted synthesis;    dicyano imidazole;    nitric acid;    metal-free oxidation catalyst;    one-step reaction;   

DOI  :  10.1080/17518253.2021.1943005

来源: Taylor & Francis

【 摘 要 】

Microwave-activated synthesis is a special and remarkable technique in modern synthetic organic chemistry. In the current research, it is described the microwave-assisted synthesis of 2-aryl-4,5-dicarbonitrile imidazole derivatives via a one-step reaction between aromatic aldehydes and 2,3-diaminomaleonitrile (DAMN) using HNO3 as a metal-free catalyst and a strong oxidizing agent. The present methodology has significant advantages as like as one-step synthesis, shorter reaction times, available starting materials, and higher yields of products with easy purification process, cleaner reaction than the previously reported processes. The valuable benefits of this method have provided a promising prospect for easier, greener, and faster synthesis of diciano imidazoles.

【 授权许可】

CC BY