Isoquinoline skeleton synthesis via chelation-assisted C-H activation

TETRAHEDRON LETTERS

卷:55

Article

He, Ruoyu¹  Huang, Zhi-Tang¹  Zheng, Qi-Yu¹  Wang, Congyang¹ 

[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China

关键词: Isoquinolines;    C-H activation;    Annulation;   

DOI  :  10.1016/j.tetlet.2014.08.077

来源: Elsevier

【 摘 要 】

Transition-metal-catalyzed isoquinoline synthesis that profits from the strategy of chelation-assisted C-H activation has flourished over the past decade. By virtue of the directed C-H bond cleavage of imines, amines, amidines, oximes, hydroximoyl halides, hydrazones, or azines, diverse isoquinoline derivatives have been accessed from alkynes, conjugated dienes, or diazo compounds under the catalysis of rhodium, ruthenium, palladium, nickel, or manganese. This digest summarizes the annulation reactions via chelation-assisted C-H activation leading to isoquinolines, isoquinolinium salts, or isoquinoline N-oxides. (C) 2014 The Authors. Published by Elsevier Ltd.

【 授权许可】

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