Highly selective fluorescent recognition of glutathione by using a water soluble binaphthyl aldehyde

TETRAHEDRON LETTERS

卷:58

Article

Chen, Wei¹  Wu, Xuedan¹  Pu, Lin¹ 

[1] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA

关键词: Fluorescence sensor;    Glutathione;    Zinc;    BINOL;    Aldehyde;   

DOI  :  10.1016/j.tetlet.2017.03.074

来源: Elsevier

【 摘 要 】

A water soluble binaphthyl-based aldehyde was designed and synthesized. This compound in combination with Zn(OAc)(2) is found to exhibit greatly enhanced fluorescence in the presence of GSH in aqueous solution (pH = 7.5) but give little or no fluorescence enhancement in the presence of cysteine, homocysteine and other amino acids. This remarkable selectivity makes this probe potentially useful for the analysis of the biologically important GSH. (C) 2017 Elsevier Ltd. All rights reserved.

【 授权许可】

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