Silver-mediated radical aryltrifluoromethylthiolation of activated alkenes by S-trifluoromethyl 4-methylbenzenesulfonothioate

TETRAHEDRON LETTERS

卷:59

Article

Zhao, Xia¹  Yang, Bo¹  Wei, Aoqi¹  Sheng, Jianqiao¹  Tian, Miaomiao¹  Li, Quan²  Lu, Kui² 

[1] Tianjin Normal Univ, Coll Chem, Tianjin Key Lab Struct & Performance Funct Mol, Minist Educ,Key Lab Inorgan Organ Hybrid Funct Ma, Tianjin 300387, Peoples R China

[2] Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin 300457, Peoples R China

关键词: Silver-mediated;    Radical;    Aryltrifluoromethylthiolation;    Activated alkenes;    Oxindole;   

DOI  :  10.1016/j.tetlet.2018.03.058

来源: Elsevier

【 摘 要 】

Herein, we describe the preparation of trifluoromethylthiol-substituted oxindoles by silver-mediated aryltrifluoromethylthiolation of activated alkenes, using S-trifluoromethyl 4-methylbenzenesulfonothioate as a F3CS radical source and showing that the reagent availability, mild conditions, and broad functional group compatibility of this transformation make it a viable alternative strategy of constructing C-sp3-SCF3 bonds. (C) 2018 Elsevier Ltd. All rights reserved.

【 授权许可】

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