Synthesis of luminescent 2,3-diphenylmaleimide-labelled peptide nucleic acid oligomers

TETRAHEDRON LETTERS

卷:59

Article

Ramani, Prasanna¹  Cauteruccio, Silvia²  Licandro, Emanuela²  Baldoli, Clara³ 

[1] Amrita Vishwa Vidyapeetham, Amrita Sch Engn, Dhanvanthri Lab, Dept Sci, Coimbatore, Tamil Nadu, India

[2] Univ Milan, Dipartimento Chim, Via C Golgi 19, I-20133 Milan, Italy

[3] CNR, Ist Sci & Tecnol Mol, Via C Golgi 19, I-20133 Milan, Italy

关键词: Peptide nucleic acids;    Solid phase synthesis;    Amino acids;    Maleimides;    Luminescence;   

DOI  :  10.1016/j.tetlet.2018.03.060

来源: Elsevier

【 摘 要 】

A lys-GTAGATCACT-lys peptide nucleic acid (PNA) decamer labelled with the luminescent 2,3-diphenyl maleimido (DPM) group on the epsilon-position of the terminal lysine residue was prepared through an automated solid phase synthesis. Fluorescence emission of the DPM-labelled PNA thus obtained was found to be significant and promising for the potential application in DNA recognition. (C) 2018 Published by Elsevier Ltd.

【 授权许可】

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