Semi-Synthesis of new glycosidic triazole derivatives of dihydrocucurbitacin B

TETRAHEDRON LETTERS

卷:56

Article

Morotti, Ana L. M.¹  Lang, Karen L.²  Carvalho, Ivone³  Schenkel, Eloir P.¹  Bernardes, Lilian S. C.¹ 

[1] Univ Fed Santa Catarina, Dept Ciencias Farmaceut, Programa Posgrad Farm, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Juiz Fora, Dept Farm, BR-35010177 Governador Valadares, MG, Brazil

[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil

关键词: Cucurbitacin;    Cucurbitacin glycosides;    Triazole derivatives;    Cycloaddition reaction;    Molecular modification;   

DOI  :  10.1016/j.tetlet.2014.11.049

来源: Elsevier

【 摘 要 】

Cucurbitacins are natural triterpenoids to which several biological activities are attributed. These molecules can be isolated as free aglycones or as glycosides, despite cucurbitacin glycosides being difficult to be obtained from natural sources. In this work, we report the synthesis of a new 2-beta-O-galactoside of dihydrocucurbitacin B and also the synthesis of eight new glycosides containing triazole moiety between the cucurbitane skeleton and the monosaccharidic unit. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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