Synthetic strategies for preparation of cyclen-based MRI contrast agents

TETRAHEDRON LETTERS

卷:56

Article

Cakic, Nevenka¹  Guenduez, Serhat¹  Rengarasu, Rathikrishnan¹  Angelovski, Goran¹ 

[1] Max Planck Inst Biol Cybernet, MR Neuroimaging Agents Grp, D-72076 Tubingen, Germany

关键词: Cyclen;    Macrocyclic ligands;    Magnetic resonance imaging;    Lanthanide complexes;   

DOI  :  10.1016/j.tetlet.2014.12.087

来源: Elsevier

【 摘 要 】

Cyclen-based macrocyclic ligands have an essential role in the development of contrast agents for magnetic resonance imaging (MRI). A prevailing need for preparation of multifunctional probes triggered a number of attempts to synthesize and derivatize ligands which efficiently chelate lanthanide ions and have advantageous MRI properties. This digest Letter summarizes the most common synthetic approaches for the preparation of macrocyclic ligands based on cyclen depending on the desired application. (C) 2014 Published by Elsevier Ltd.

【 授权许可】

Free