Towards the design, synthesis and preliminary biological evaluation of potential corono and clipcarbenes: Novel bis-imidazolium-bis- heterocycle macrocyclic ligands

TETRAHEDRON LETTERS

卷:79

Article

Hussein, Hiba¹  Varbanov, Mihayl¹  Fournier, Bertrand^2,3  Dumarcay-Charbonnier, Florence¹ 

[1] Univ Lorraine, CNRS, L2CM, F-54000 Nancy, France

[2] Univ Paris Saclay, CNRS, Inst Galien Paris Saclay, UMR 8612, F-92296 Chatenay Malabry, France

[3] Univ Paris Saclay, CNRS UMR 8580, CentraleSupelec, Lab Struct Proprietes & Modelisat Solides, F-91190 Gif Sur Yvette, France

关键词: Macrocyclic ligands;    Bipyridine;    Bithiazole;    Imidazolium salts;    Cytotoxicity and antibacterial activity;    Crystallographic structures;   

DOI  :  10.1016/j.tetlet.2021.153288

来源: Elsevier

【 摘 要 】

The synthesis of novel macrocyclic N-bis-imidazolium-bis-heterocyclic carbenes (NHCs) with rigid and constrained structures to improve the stability of their transition metal coordination complexes in order to obtain efficient photosensitizers is reported. Two pathways have been developed for the preparation of coronocarbenes (L1-L3) containing bipyridine or bithiazole groups. Flexible hemi-macrocycles with potential as clipcarbenes (L1 ''-L3 '') are also described. The crystal structures of ligands L1 and L3 are detailed and the preliminary biological evaluation of L1-L3 is presented. (C) 2021 Elsevier Ltd. All rights reserved.

【 授权许可】

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