Peroxide-mediated oxidative coupling of primary alcohols and disulfides: Synthesis of 2-substituted benzothiazoles

TETRAHEDRON LETTERS

卷:60

Article

Padilha, Nathalia B.¹  Penteado, Filipe¹  Salomao, Maria C.¹  Lopes, Eric F.¹  Bettanin, Luana¹  Hartwig, Daniela¹  Jacob, Raquel G.¹  Lenardao, Eder J.¹ 

[1] Univ Fed Pelotas, Lab Sintese Organ Limpa, CCQFA, UFPel,LASOL, POB 354, BR-96010900 Pelotas, RS, Brazil

关键词: Benzothiazoles;    C-S bond formation;    Oxidative coupling;    Disulfides;   

DOI  :  10.1016/j.tetlet.2019.05.021

来源: Elsevier

【 摘 要 】

A peroxide-mediated protocol for the synthesis of 2-substituted benzothiazoles was developed, starting from bis(o-aminophenyl) disulfides and primary alcohols. Eleven differently 2-substituted benzothiazoles were prepared in moderate to excellent yields using di-tert-butyl peroxide (DTBP) as an oxidant. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

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