Transition Metal Catalyzed Synthesis of Aryl Sulfides

Molecules

Chad C. Eichman¹ 

[1] Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA

关键词: C-S bond formation;    biaryl sulfides;    arylation of thiols;   

DOI  :  10.3390/molecules16010590

来源: mdpi

【 摘 要 】

The presence of aryl sulfides in biologically active compounds has resulted in the development of new methods to form carbon-sulfur bonds. The synthesis of aryl sulfides via metal catalysis has significantly increased in recent years. Historically, thiolates and sulfides have been thought to plague catalyst activity in the presence of transition metals. Indeed, strong coordination of thiolates and thioethers to transition metals can often hinder catalytic activity; however, various catalysts are able to withstand catalyst deactivation and form aryl carbon-sulfur bonds in high-yielding transformations. This review discusses the metal-catalyzed arylation of thiols and the use of disulfides as metal-thiolate precursors for the formation of C-S bonds.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.