Synthetic studies towards anti-SARS agents:: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate

TETRAHEDRON LETTERS

卷:45

Article

Chng, SS ; Hoang, TG ; Lee, WWW ; Tham, MP ; Ling, HY ; Loh, TP

关键词: anti-SARS agents;    AG7088;    indium-mediated allylation;    diastereoselective;   

DOI  :  10.1016/j.tetlet.2004.10.146

来源: Elsevier

【 摘 要 】

AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M-pro). Synthesis of intermediate I and analogues proceeded via a highly diastereoselective indium-mediated allylation of alpha-aminoaldehydes. (C) 2004 Elsevier Ltd. All rights reserved.

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