Highly Diastereoselective Synthesis of Spiropyrazolones

Molecules

Victor Ceban¹  Temitope O. Olomola¹  Marta Meazza¹  Ramon Rios¹ 

[1] Faculty of Natural & Environmental Sciences, University of Southampton Highfield Campus, Southampton SO17 1BJ, UK; E-Mails:

关键词: spiropyrazolones;    diastereoselective;    cascade reaction;   

DOI  :  10.3390/molecules20058574

来源: mdpi

【 摘 要 】

We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.