Diastereoselective Synthesis of 5-Hydroxy-8-methoxy-1-oxaspiro[5,5]undeca-7,10-diene-9-one

Molecules

卷:18

关键词: synthesis;    diastereoselective;    spirolactone;    spiroether;    spirocompound;    dienone;    oxidation;    lead tetraacetate;   

DOI  :  10.3390/molecules18011174

来源: DOAJ

【 摘 要 】

A short five steps synthesis of the title compound from vanillin is described. The racemic spiroether 7 was obtained in 61% yield and in >99% diastereomeric excess (by 1H-NMR) from the corresponding phenolic derivative 3 by oxidation with lead (IV) acetate.

【 授权许可】

Unknown