Pinnatoxin H: a new pinnatoxin analogue from a South China Sea Vulcanodinium rugosum isolate

TETRAHEDRON LETTERS

卷:55

Article

Selwood, Andrew I.¹  Wilkins, Alistair L.²  Munday, Rex³  Gu, Haifeng⁴  Smith, Kirsty F.¹  Rhodes, Lesley L.¹  Rise, Frode⁵ 

[1] Cawthron Inst, Nelson, New Zealand

[2] Univ Waikato, Dept Chem, Hamilton, New Zealand

[3] AgResearch Ltd, Ruakura Res Ctr, Hamilton, New Zealand

[4] SOA, Inst Oceanog 3, Xiamen 361005, Peoples R China

[5] Univ Oslo, NO-0315 Oslo, Norway

关键词: Pinnatoxin;    Portimine;    Vulcanodinium;    Cyclic imine;    Algal toxin;   

DOI  :  10.1016/j.tetlet.2014.08.056

来源: Elsevier

【 摘 要 】

Pinnatoxin H was isolated from a culture of the dinoflagellate Vulcanodinium rugosum isolated from the South China Sea. The structure of pinnatoxin H was elucidated by LC-MS/MS and NMR spectroscopy. It was found to have the same macrocyclic structure and substituents as pinnatoxins D, E and F, but the side chain on the cyclohexenyl ring was an ethenyl group, as found in pinnatoxin G and portimine. The observation that this strain of V. rugosum produced only pinnatoxin H and portimine is consistent with previous findings that the profile of pinnatoxins can vary significantly among strains. The acute toxicity of pinnatoxin H to mice was 67 mu g/kg (intraperitoneal) and 163 mu g/kg (gavage). (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

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