Enantioselective addition of Et2Zn to seven-membered cyclic imines catalyzed by a (R)-VAPOL-Zn(II) complex

TETRAHEDRON LETTERS

卷:58

Article

De Munck, Lode¹  Sukowski, Verena¹  Vila, Carlos¹  Pedro, Jose R.¹ 

[1] Univ Valencia, Fac Quim, Dept Quim Organ, Dr Moliner 50, E-46100 Valencia, Spain

关键词: Zinc;    Dibenzo[bj][1,4]oxazepine;    Asymmetric catalysis;    VAPOL;    Cyclic imine;   

DOI  :  10.1016/j.tetlet.2017.07.042

来源: Elsevier

【 摘 要 】

Various substituted dibenzo[bj][1,4]ozazepines underwent an enantioselective alkylation with Et2Zn catalyzed by a (R)-VAPOL-Zn(II) complex. The corresponding chiral 11-ethyl-10,11-dihydrodibenzo[bj] [1,4]oxazepine derivatives were obtained with good yields and moderate enantioselectivities. This represents the first example of enantioselective addition of Et2Zn to cyclic aldimines. (C) 2017 Elsevier Ltd. All rights reserved.

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