Pd(II)-catalyzed diastereoselective and enantioselective domino cyclization/cycloaddition reactions of alkenyl oximes for polycyclic heterocycles with four chiral stereogenic centers

TETRAHEDRON LETTERS

卷:56

Article

Abozeid, Mohamed A.¹  Takizawa, Shinobu¹  Sasai, Hiroaki¹ 

[1] Osaka Univ, Inst Sci & Ind Res, Ibaraki, Osaka 5670047, Japan

关键词: Stereoselective reaction;    Domino reaction;    Cyclization;    Cycloaddition;    Isoxazolidine;   

DOI  :  10.1016/j.tetlet.2015.05.070

来源: Elsevier

【 摘 要 】

Diastereoselective and enantioselective domino cyclization/cycloaddition reactions of alkenyl oximes were established using a Pd(II)-(R)-Tol-SDP complex and triflic acid. The present process gave polycyclic heterocycles with four chiral stereogenic centers in almost quantitative yields and high stereoselectivities (up to 70% ee, exo/endo = 97/3). (c) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free