Synthesis and free radical scavenging activity of 2-alkyl/arylchalcogenyl-N-(4-aryl-1,3-thiazol-2-yl)acetamide compounds

TETRAHEDRON LETTERS

卷:57

Article

Wolf, Lucas¹  Quoos, Natalia¹  Mayer, Joao C. P.¹  de Souza, Diego¹  Sauer, Andre C.¹  Meichtry, Luana²  Bortolotto, Vandreza²  Prigol, Marina²  Rodrigues, Oscar E. D.¹  Dornelles, Luciano¹ 

[1] Univ Fed Santa Maria, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

[2] Univ Fed Pampa, UNIPAMPA, Campus Itaqui, BR-97650000 Itaqui, RS, Brazil

关键词: Heterocyclic;    Thiazole;    Organochalcogen;    Antioxidant effect;   

DOI  :  10.1016/j.tetlet.2016.01.079

来源: Elsevier

【 摘 要 】

The synthesis of a new series of organochalcogen-derivatives, 2-alkyl/arylchalcogenyl-N-(4-aryl-1,3-thiazol-2-yl)acetamides 5a-r, provided products in satisfactory yields, which varied from 42% to 95%. All these novel compounds were screened for their in vitro free radical scavenging activity against 2,2-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals. Compounds 5 (m, h, i, f, q, g, l, c, n) were effective scavengers against the ABTS radical species but less effective on scavenging the DPPH radical, indicating that the antioxidant effect of these compounds were related to protonated radical scavenger activity. (C) 2016 Elsevier Ltd. All rights reserved.

【 授权许可】

Free