Dosimetric and radiobiological comparison between conventional and hypofractionated breast treatment plans using the Halcyon system

Frontiers in Oncology

Oncology

David Bradley¹  Nguyen Xuan Hai²  Huynh Van Tran Sang³  Tran Minh Loc³  Duong Thanh Tai⁴  Peter A. Sandwall⁵  Luong Tien Phat⁶  James C. L. Chow⁷  Nguyen Ngoc Anh⁸ 

[1] Centre for Applied Physics and Radiation Technologies, Sunway University, Sunway, Malaysia;School of Mathematics and Physics, University of Surrey, Guildford, United Kingdom;Dalat Nuclear Research Institute, Dalat, Vietnam;Department of Medical Physics, Faculty of Medicine, Nguyen Tat Thanh University, Ho Chi Minh, Vietnam;Department of Medical Physics, Faculty of Medicine, Nguyen Tat Thanh University, Ho Chi Minh, Vietnam;Robarts Research Institute, University of Western Ontario, London, ON, Canada;Department of Radiation Oncology, OhioHealth, Mansfield Hospital, Mansfield, OH, United States;Department of Radiation Oncology, University Medical Shing Mark Hospital, Bien Hoa, Vietnam;Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada;Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, ON, Canada;Faculty of Fundamental Science, PHENIKAA University, Hanoi, Vietnam;PHENIKAA Research and Technology Institute (PRATI), A&A Green Phoenix Group JSC, Hanoi, Vietnam;

关键词: radiotherapy treatment plan;    conventional fractionated (CF);    hypofractionated (HF);    breast cancer;    radiobiology model;    Halcyon;    normal tissue complication probability (NTCP);    tumor control probability (TCP);   

DOI  :  10.3389/fonc.2023.1259416

 received in 2023-07-15, accepted in 2023-09-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

PurposeThe objective of this research is to compare the efficacy of conventional and hypofractionated radiotherapy treatment plans for breast cancer patients, with a specific focus on the unique features of the Halcyon system.Methods and materialsThe study collected and analyzed dose volume histogram (DVH) data for two groups of treatment plans implemented using the Halcyon system. The first group consisted of 19 patients who received conventional fractionated (CF) treatment with a total dose of 50 Gy in 25 fractions, while the second group comprised 9 patients who received hypofractionated (HF) treatment with a total dose of 42.56 Gy in 16 fractions. The DVH data was used to calculate various parameters, including tumor control probability (TCP), normal tissue complication probability (NTCP), and equivalent uniform dose (EUD), using radiobiological models.ResultsThe results indicated that the CF plan resulted in higher TCP but lower NTCP for the lungs compared to the HF plan. The EUD for the HF plan was approximately 49 Gy (114% of its total dose) while that for the CF plan was around 53 Gy (107% of its total dose).ConclusionsThe analysis suggests that while the CF plan is better at controlling tumors, it is not as effective as the HF plan in minimizing side effects. Additionally, it is suggested that there may be an optimal configuration for the HF plan that can provide the same or higher EUD than the CF plan.

【 授权许可】

Unknown   
Copyright © 2023 Tai, Phat, Ngoc Anh, Sang, Loc, Hai, Sandwall, Bradley and Chow