MXene-enhanced ePatch with antibacterial activity for wound healing

Frontiers in Chemistry

Chemistry

Sai Ma¹  Xuefeng Yuan²  Jing Feng²  Zhaorui Sun²  Ji Xie²  Rui Liu²  Changkui Cao²  Shinan Nie² 

[1] Department of Cardiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China;Department of Cardiology, The First School of Clinical Medicine, Southern Medical University, Nanjing, China;Department of Emergency Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China;Department of Emergency Medicine, The First School of Clinical Medicine, Southern Medical University, Nanjing, China;

关键词: MXene;    ePatch;    wound healing;    hydrogel;    enhanced;   

DOI  :  10.3389/fchem.2023.1280040

 received in 2023-08-19, accepted in 2023-10-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Prudent wound-healing strategies hold great potential in expediting tissue renovation and regeneration. Despite the widespread adoption of hydrogels as preferred carriers for wound healing patches, achieving optimal mechanical compatibility and superior wound performance remains a formidable challenge. Consequently, meticulous attention must be given to the formulation of hydrogel structure and materials design to overcome these hurdles. In response, we have developed an ePatch composed of polyacrylamide (PAAM) as the primary hydrogel structure, augmented with MXene, silver nanowires (AgNWs), and resveratrol to act as sustained-release agents, structural enhancers, and antibacterial agents, respectively. Notably, the ePatch exhibited exceptional wound-fitting capabilities and impressive mechanical stretchability (with a relative standard deviation [RSD] of only 1.36% after 55 stretches) and Young’s modulus. In contrast to the commercial 3M Tegaderm, the ePatch demonstrated superior wound healing properties, with the inclusion of MXene into PAAM/AgNWs playing a pivotal role in expanding the ePatch’s potential use across various interconnected fields.

【 授权许可】

Unknown   
Copyright © 2023 Feng, Liu, Yuan, Cao, Xie, Sun, Ma and Nie.