The role and mechanism of inflammatory response to growing rod implantation in early onset scoliosis

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Zhiyi Li¹  Bingtai Han¹  Yang Yang¹  You Du¹  Haoran Zhang¹  Yiwei Zhao¹  Shengru Wang²  Jianguo Zhang³ 

[1] Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China;[e-mail];null;

关键词: growing rod;    early onset scoliosis;    metalosis;    inflammatory response;    NLRP3 inflammasome;   

DOI  :  10.3389/fcell.2023.1282573

 received in 2023-08-24, accepted in 2023-10-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

Growing rod implantation, a surgery treatment for EOS (early onset scoliosis), may cause a kind of chronic inflammation called metalosis and all other implant-related complications because of the metal debris released by the implants as a result of fraction and corrosion. There is no complete explanation of immunologic mechanisms of metalosis up to now. This review demonstrates the researches on metalosis from the clinical issues down to basic immunologic mechanisms. Adverse reactions of metal implants are mainly the formation of NLRP3 (nod-like receptor protein 3) inflammasome, primed by TLR4 (toll-like receptor protein 4), activated by phagocytosis and often accompanied by type Ⅳ hypersensitive reaction. Recent studies found that TNF-α (tumor necrosis factor α) also participates in priming, and activation of inflammasome requires disturbance of lysosome and release of cathepsin B. Ca-074Me and MCC950 are therapeutic interventions worth exploring in aseptic loosening of orthopedic implants.

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Han, Li, Zhao, Du, Yang, Wang and Zhang.