Association of cholecystectomy with osteoporosis risk: a prospective study using data from the UK Biobank

Frontiers in Endocrinology

Endocrinology

Congying Xia¹  Lu Long²  Tongtong Zhang³  Jun Wen⁴  Qin Yang⁴  Ming Wang⁴ 

[1] Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China;Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China;Department of General Surgery, The Third People’s Hospital of Chengdu and The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China;Section for HepatoPancreatoBiliary Surgery, Department of General Surgery, The Third People’s Hospital of Chengdu and The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China;

关键词: cholecystectomy;    osteoporosis;    cohort;    risk factor;    gender difference;    interaction;   

DOI  :  10.3389/fendo.2023.1259475

 received in 2023-07-16, accepted in 2023-10-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveTo investigate whether prior cholecystectomy is associated with incident osteoporosis.BackgroundCholecystectomy may have consequences involving abnormal metabolism. Studies investigating the association between prior cholecystectomy and osteoporosis have yielded inconsistent results.MethodsIn total, 17,603 UK Biobank participants underwent cholecystectomy, and 35,206 matched controls were included in this study. They were followed up for incident osteoporosis, which was determined using ICD-10 codes (M80–82). The association between cholecystectomy and osteoporosis was assessed using Cox proportional regression modeling. The association between osteoporosis risk and cholecystectomy was further analyzed across age, sex, serum vitamin D level, and body mass index (BMI) categories.ResultsWithin a median follow-up period of 13.56 years, 3,217 participants were diagnosed with osteoporosis. After adjustment for relevant confounders, prior cholecystectomy was associated with a 1.21 times higher risk of osteoporosis in women (hazard ratio (HR): 1.21 [95% CI, 1.12–1.31], p < 0.001) and a 1.45 times higher risk in men (HR: 1.45 [95% CI, 1.10–1.90], p = 0.007). In women, the association was stronger for patients who were aged 40–55 years, with BMI < 18.5 kg/m2, and vitamin D between 30 and 50 nmol/ml. No significant interactions between cholecystectomy and income level, education level, presence of hypertension, or diabetes were identified in either sex.ConclusionsOur findings indicated that people who underwent cholecystectomy had a higher risk of developing osteoporosis after adjustment for potential confounders. Our findings suggest that awareness of the risk of osteoporosis in patients with a history of cholecystectomy is merited.

【 授权许可】

Unknown   
Copyright © 2023 Yang, Wang, Zhang, Wen, Long and Xia