Shared genetic architecture of COVID-19 and Alzheimer’s disease

Frontiers in Aging Neuroscience

Aging Neuroscience

Viktor Kakotkin¹  Mikhail Agapov¹  Ekaterina Semina¹  Olga Favorova²  Ivan Kiselev²  Olga Kulakova²  Natalia Matveeva²  Natalia Baulina² 

[1] Institute of Medicine and Life Science, Immanuel Kant Baltic Federal University, Kaliningrad, Russia;Institute of Medicine and Life Science, Immanuel Kant Baltic Federal University, Kaliningrad, Russia;Laboratory of Medical Genomics, Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia;

关键词: COVID-19;    long Covid;    Alzheimer’s disease;    cognitive impairment;    pathway analysis;    genetic susceptibility;    GWAS;    SNP;   

DOI  :  10.3389/fnagi.2023.1287322

 received in 2023-09-01, accepted in 2023-10-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

The severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the сoronavirus disease 2019 (COVID-19) have become a global health threat. At the height of the pandemic, major efforts were focused on reducing COVID-19-associated morbidity and mortality. Now is the time to study the long-term effects of the pandemic, particularly cognitive impairment associated with long COVID. In recent years much attention has been paid to the possible relationship between COVID-19 and Alzheimer’s disease, which is considered a main cause of age-related cognitive impairment. Genetic predisposition was shown for both COVID-19 and Alzheimer’s disease. However, the analysis of the similarity of the genetic architecture of these diseases is usually limited to indicating a positive genetic correlation between them. In this review, we have described intrinsic linkages between COVID-19 and Alzheimer’s disease, pointed out shared susceptibility genes that were previously identified in genome-wide association studies of both COVID-19 and Alzheimer’s disease, and highlighted a panel of SNPs that includes candidate genetic risk markers of the long COVID-associated cognitive impairment.

【 授权许可】

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Copyright © 2023 Matveeva, Kiselev, Baulina, Semina, Kakotkin, Agapov, Kulakova and Favorova.