Molecular pathogenesis of Chlamydia trachomatis

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Wilhelmina M. Huston¹  Laurence Don Wai Luu²  Charlotte Fleming²  Brittany Jury² 

[1] Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia;School of Life Sciences, Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia;

关键词: Chlamydia trachomatis;    pathogenesis;    virulence;    immune evasion;    type III secretion system;    proteases;    cytotoxin;    polymorphic membrane proteins;   

DOI  :  10.3389/fcimb.2023.1281823

 received in 2023-08-23, accepted in 2023-10-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

Chlamydia trachomatis is a strict intracellular human pathogen. It is the main bacterial cause of sexually transmitted infections and the etiologic agent of trachoma, which is the leading cause of preventable blindness. Despite over 100 years since C. trachomatis was first identified, there is still no vaccine. However in recent years, the advancement of genetic manipulation approaches for C. trachomatis has increased our understanding of the molecular pathogenesis of C. trachomatis and progress towards a vaccine. In this mini-review, we aimed to outline the factors related to the developmental cycle phase and specific pathogenesis activity of C. trachomatis in order to focus priorities for future genetic approaches. We highlight the factors known to be critical for developmental cycle stages, gene expression regulatory factors, type III secretion system and their effectors, and individual virulence factors with known impacts.

【 授权许可】

Unknown   
Copyright © 2023 Jury, Fleming, Huston and Luu