The importance of immune evasion in the pathogenesis of rabies virus

Journal of Veterinary Medical Science

Naoto ITO¹  Gregory W. MOSELEY²  Makoto SUGIYAMA¹ 

[1] Laboratory of Zoonotic Diseases, Faculty of Applied Biological Sciences, Gifu University, 1�?1 Yanagido, Gifu, Gifu 501�?1193, Japan;Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Rd., The University of Melbourne, Victoria 3010, Australia

关键词: immune evasion;    interferon;    lyssavirus;    pathogenesis;    rabies;   

DOI  :  10.1292/jvms.16-0092

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(78)Rabies is a zoonotic disease caused by the Lyssavirus rabies virus(RABV) that can infect most mammals, including humans, where it has a case-fatality rateof almost 100%. Although preventable by vaccination, rabies causes c. 59,000 humanfatalities every year worldwide. Thus, there exists an urgent need to establish aneffective therapy and/or improve dissemination of vaccines for humans and animals. Theseoutcomes require greater understanding of the mechanisms of RABV pathogenesis to identifynew molecular targets for the development of therapeutics and/or live vaccines with highlevels of safety. Importantly, a number of studies in recent years have indicated thatRABV specifically suppresses host immunity through diverse mechanisms and that this is akey process in pathogenicity. Here, we review current understanding of immune modulationby RABV, with an emphasis on its significance to pathogenicity and the potentialexploitation of this knowledge to develop new vaccines and antivirals.

【 授权许可】

Unknown