The Interplay of Obesity, Dyslipidemia and Immune Dysfunction: A Brief Overview on Pathophysiology, Animal Models, and Nutritional Modulation

Frontiers in Nutrition

Nutrition

Sue Tsai¹  Yongbo She²  Rabban Mangat²  Spencer D. Proctor²  Caroline Richard³ 

[1] Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada;Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada;Metabolic and Cardiovascular Diseases Laboratory, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada;Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada;Metabolic and Cardiovascular Diseases Laboratory, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada;Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada;

关键词: obesity;    insulin resistance;    dyslipidemia;    immune function;    nutrition;   

DOI  :  10.3389/fnut.2022.840209

 received in 2021-12-20, accepted in 2022-01-20,  发布年份 2022

来源: Frontiers

【 摘 要 】

Obesity has emerged as a leading global health concern. It is characterized by chronic low-grade inflammation, which impairs insulin signaling, lipid metabolism and immune function. Recent findings from animal and clinical studies have begun to elucidate the underlying mechanisms of immune dysfunction seen in the context of obesity. Here, we provide a brief review on the current understanding of the interplay between obesity, dyslipidemia and immunity. We also emphasize the advantages and shortcomings of numerous applicable research models including rodents and large animal swine that aim at unraveling the molecular basis of disease and clinical manifestations. Although there is no perfect model to answer all questions at once, they are often used to complement each other. Finally, we highlight some emerging nutritional strategies to improve immune function in the context of obesity with a particular focus on choline and foods that contains high amounts of choline.

【 授权许可】

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Copyright © 2022 She, Mangat, Tsai, Proctor and Richard.