Effect of prior female SARS-CoV-2 infection on IVF outcomes: a prospective cohort study

Frontiers in Endocrinology

Endocrinology

Qiqi Xie¹  Yunjun Li¹  Yan Zhao¹  Yina Hu¹  Jialyu Huang¹  Jia Chen¹  Qiongfang Wu¹  Dingfei Xu¹  Leizhen Xia¹  Lifeng Tian¹  Qiong Su¹  Yuxin Liu²  Xiaoyan Ai³  Jiawei Wang⁴ 

[1] Center for Reproductive Medicine, Jiangxi Key Laboratory of Women’s Reproductive Health, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, China;Department of Clinical Medicine, School of Queen Mary, Nanchang University, Nanchang, China;Department of Gynecology, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Nanchang Medical College, Nanchang, China;Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China;

关键词: COVID-19;    SARS-CoV-2;    infection;    pregnancy;    in vitro;   

DOI  :  10.3389/fendo.2023.1239903

 received in 2023-06-14, accepted in 2023-09-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionThe clinical impact of SARS-CoV-2 infection on human reproduction remains controversial. This prospective cohort study aimed to assess the effect of prior female SARS-CoV-2 infection on subsequent in vitro fertilization (IVF) outcomes.Materials and methodsA total of 451 women who underwent fresh IVF treatment between December 1, 2022 and April 30, 2023 were included from an academic fertility center. Participants were divided into the infected group if they had a prior COVID-19 history before cycle initiation (n = 252), while the control group were those uninfected (n = 199). The primary outcomes were the number of oocytes retrieved and clinical pregnancy rate after fresh embryo transfer. Multivariate linear and logistic regression analyses were conducted to control for potential confounders.ResultsThe number of oocytes retrieved (11.4 ± 8.3 vs. 11.6 ± 7.7; P = 0.457) and clinical pregnancy rate (70.3% vs. 73.7%; P = 0.590) were similar between infected and uninfected groups, with a fully adjusted β coefficient of 0 (95% confidence interval [CI]: -0.14–0.13) and odds ratio of 0.64 (95% CI: 0.20–2.07), respectively. Consistently, the two groups were comparable in cycle characteristics as well as other laboratory and pregnancy parameters. In both subgroup analyses and restricted cubic splines, different post-infection time intervals to IVF cycle initiation showed no significant associations with treatment outcomes.ConclusionPrior SARS-CoV-2 infection in females had no adverse influence on subsequent IVF treatment, regardless of the time interval following infection. Our findings provide reassurance for infected women planning for assisted reproduction. Additional prospective cohort studies with larger datasets and longer follow-up are required to confirm the conclusion.

【 授权许可】

Unknown   
Copyright © 2023 Huang, Liu, Xia, Zhao, Tian, Xu, Su, Hu, Xie, Chen, Li, Ai, Wang and Wu