Ion channels in lung cancer: biological and clinical relevance

Frontiers in Pharmacology

Pharmacology

Elena Lastraioli¹  Chiara Capitani²  Ginevra Chioccioli Altadonna²  Michele Santillo² 

[1] General Pathology Laboratory, Department of Experimental and Clinical Medicine, Internal Medicine Section, University of Florence, Florence, Italy;General Pathology Laboratory, Department of Experimental and Clinical Medicine, Internal Medicine Section, University of Florence, Florence, Italy;Department of Medical Biotechnologies, University of Siena, Siena, Italy;

关键词: lung cancer;    SCLC;    NSCLC;    potassium channels;    sodium channels;    calcium channels;    chloride channels;    anion channels;   

DOI  :  10.3389/fphar.2023.1283623

 received in 2023-08-26, accepted in 2023-10-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

Despite improvements in treatment, lung cancer is still a major health problem worldwide. Among lung cancer subtypes, the most frequent is represented by adenocarcinoma (belonging to the Non-Small Cell Lung Cancer class) although the most challenging and harder to treat is represented by Small Cell Lung Cancer, that occurs at lower frequency but has the worst prognosis. For these reasons, the standard of care for these patients is represented by a combination of surgery, radiation therapy and chemotherapy. In this view, searching for novel biomarkers that might help both in diagnosis and therapy is mandatory. In the last 30 years it was demonstrated that different families of ion channels are overexpressed in both lung cancer cell lines and primary tumours. The altered ion channel profile may be advantageous for diagnostic and therapeutic purposes since most of them are localised on the plasma membrane thus their detection is quite easy, as well as their block with specific drugs and antibodies. This review focuses on ion channels (Potassium, Sodium, Calcium, Chloride, Anion and Nicotinic Acetylcholine receptors) in lung cancer (both Non-Small Cell Lung Cancer and Small Cell Lung Cancer) and recapitulate the up-to-date knowledge about their role and clinical relevance for a potential use in the clinical setting, for lung cancer diagnosis and therapy.

【 授权许可】

Unknown   
Copyright © 2023 Capitani, Chioccioli Altadonna, Santillo and Lastraioli.