Cell plasticity in patients with NSCLC: The controversial origins of transformed SCLC

Biomedicine & Pharmacotherapy

Anqi Lin¹  Peng Luo²  Qiongyao Wang²  Jian Zhang²  Xinlin Liang² 

[1] The First Clinical Medical School of Southern Medical University, Guangzhou, Guangdong, 510515 China;Department of Oncology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, 510280 China;

关键词: NSCLC;    SCLC;    Transformation;    Origin;    EGFR;   

DOI  :  

来源: DOAJ

【 摘 要 】

In recent years, the application of targeted therapy has greatly improved the survival of NSCLC patients with known tumor mutations. However, the plasticity of tumor cells can drive them to transform into a phenotypic state that is no longer targeted by drugs. One of the mechanisms by which drug resistance occurs is the transformation from NSCLC to SCLC. This seems to occur because of the selection pressure exerted by the drugs. However, the transformation has also been observed in non-targeted patients, which challenges the origin of transformed SCLC. In the present study, the current clinical understanding of transformed SCLC is summarized along with the current understanding of its genome status and cloning history in cancer progression. This was done to explore the origins of transformed SCLC, find key molecular markers to predict the occurrence of the transformation, and permit timely adjustment of patients’ treatment plans. Besides, the current clinical trials on transformed SCLC are discussed. Finally, recommendations are made on the problems that need to be solved to improve the diagnosis and treatment of patients with transformed SCLC.

【 授权许可】

Unknown