Recent advances on cyclodepsipeptides: biologically active compounds for drug research

Frontiers in Microbiology

Microbiology

Si-Yi Ou-Yang¹  Yong-Fu Lu¹  Yue-Hu Pei¹  Si-Xuan Liu¹  Chun-Lin Guo¹  Si-Yang Dai¹  Chang Li²  Tian-Yi Yu³ 

[1] Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, China;Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, China;Key Laboratory of Gut Microbiota and Pharmacogenomics of Heilongjiang Province, College of Pharmacy, Harbin Medical University, Harbin, China;The Third Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China;

关键词: cyclodepsipeptide;    fungi;    bacteria;    antimicrobial;    biological activity;   

DOI  :  10.3389/fmicb.2023.1276928

 received in 2023-08-13, accepted in 2023-09-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

Cyclodepsipeptides are a large family of peptide-related natural products consisting of hydroxy and amino acids linked by amide and ester bonds. A number of cyclodepsipeptides have been isolated and characterized from fungi and bacteria. Most of them showed antitumor, antifungal, antiviral, antimalarial, and antitrypanosomal properties. Herein, this review summarizes the recent literatures (2010–2022) on the progress of cyclodepsipeptides from fungi and bacteria except for those of marine origin, in order to enrich our knowledge about their structural features and biological sources.

【 授权许可】

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Copyright © 2023 Liu, Ou-Yang, Lu, Guo, Dai, Li, Yu and Pei.