Inflammatory arthritis and eye diseases: a Mendelian randomization study

Frontiers in Endocrinology

Endocrinology

Xinlin Nie¹  Zhaoliang Liu¹  Yang Sun¹  Dongheng Xie¹ 

[1] Department of Orthopedic Center, The First Hospital of Jilin University, Changchun, China;

关键词: inflammatory arthritis;    rheumatoid arthritis;    ankylosing spondylitis;    psoriatic arthritis;    eye diseases;    Mendelian randomization;   

DOI  :  10.3389/fendo.2023.1251167

 received in 2023-07-01, accepted in 2023-09-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesThe aim of this study was to determine causal associations between inflammatory arthritis and eye diseases (disorders of sclera, cornea, iris, and ciliary body [DSCIC] and disorders of choroid and retina [DCR]).MethodsGenome-wide association studies’ summary data of rheumatoid arthritis (RA) from a large-scale meta-analysis were used to identify genetically predicted RA. UK Biobank source data predicted ankylosing spondylitis (AS), psoriatic arthritis (PsA), and juvenile idiopathic arthritis (JIA). Furthermore, data from the FinnGen Biobank were used to identify genetically predicted eye diseases. Two-sample Mendelian randomization analysis was used to assess the causal relationship between inflammatory arthritis and eye diseases in the European population. Inverse-variance weighting (IVW) was used as the primary method, while MR-Egger, weighted median, and MR-PRESSO outlier test were used to detect heterogeneity and pleiotropy.ResultsGenetically determined RA was indeed observed to have a causal effect on DSCIC (odds ratio [OR] = 1.084, p = 2.353 × 10−10) and DCR (OR = 1.151, p = 1.584 × 10−19). AS was causally associated with DSCIC (OR = 1.068, p < 2.024 × 10−8). In addition, PsA was also found to have a causal association with an increased risk of 17.9% for the development of DSCIC (OR = 1.179, p = 0.003). On the flip side, DSCIC increased the risk of JIA (OR = 2.276, p = 0.003).ConclusionOur study provided genetic evidence for the causal associations of RA, AS, and PsA with an increased risk of DSCIC, and a causal association between RA and DCR was also identified. In addition, DSCIC greatly increased the risk of JIA.

【 授权许可】

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Copyright © 2023 Nie, Liu, Xie and Sun