The Cellular Source of IL-17A in the Pathogenesis of Inflammatory Joint Diseases

Current Health Sciences Journal

COJOCARU-GOFITA I.R.replacement¹ 

关键词: rheumatoid arthritis;    psoriatic arthritis;    ankylosing spondylitis;    pro- inflammatory cytokines;   

DOI  :  10.12865/CHSJ.38.02.01

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

Abstract Inflammatory joint diseases comprise a various range of maladies such as rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis. One of their common  pathogenical features is the implication of TH1/2 cytokines(1). In addition to the well-established TH1 and 2 cytokines there has been  found a new family of cytokines and their receptors – IL-17 - which was thought to be produced mainly by the TH17 subset(1, 2). Recent findings suggest that this highly pro- inflammatory cytokine could be produced by various other cell subtypes such as mast cells(3) (4)and neutrophils. The novelty brought by the intensive research upon IL-17 in human inflammatory joint diseases may bring into clinical practice a broader therapeutical range of options for these patients(5, 6)

【 授权许可】

Unknown