Advances in mitochondria-centered mechanism behind the roles of androgens and androgen receptor in the regulation of glucose and lipid metabolism

Frontiers in Endocrinology

Endocrinology

Shuo Qi¹  Lijun Yin²  Zhiqiang Zhu² 

[1] School of Sport Health, Shandong Sport University, Jinan, China;School of Sport, Shenzhen University, Shenzhen, China;

关键词: androgen;    androgen receptor;    mitochondria;    glucose metabolism;    lipid metabolism;    signaling;   

DOI  :  10.3389/fendo.2023.1267170

 received in 2023-07-26, accepted in 2023-09-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

An increasing number of studies have reported that androgens and androgen receptors (AR) play important roles in the regulation of glucose and lipid metabolism. Impaired glucose and lipid metabolism and the development of obesity-related diseases have been found in either hypogonadal men or male rodents with androgen deficiency. Exogenous androgens supplementation can effectively improve these disorders, but the mechanism by which androgens regulate glucose and lipid metabolism has not been fully elucidated. Mitochondria, as powerhouses within cells, are key organelles influencing glucose and lipid metabolism. Evidence from both pre-clinical and clinical studies has reported that the regulation of glucose and lipid metabolism by androgens/AR is strongly associated with the impact on the content and function of mitochondria, but few studies have systematically reported the regulatory effect and the molecular mechanism. In this paper, we review the effect of androgens/AR on mitochondrial content, morphology, quality control system, and function, with emphases on molecular mechanisms. Additionally, we discuss the sex-dimorphic effect of androgens on mitochondria. This paper provides a theoretical basis for shedding light on the influence and mechanism of androgens on glucose and lipid metabolism and highlights the mitochondria-based explanation for the sex-dimorphic effect of androgens on glucose and lipid metabolism.

【 授权许可】

Unknown   
Copyright © 2023 Yin, Qi and Zhu