Monthly versus daily administration of vitamin D3 in children: a retrospective propensity score-matched study

Frontiers in Endocrinology

Endocrinology

Yunsoo Choe¹  Jinjoo Choi²  Seung Yang³ 

[1] Department of Pediatrics, Hanyang University Guri Hospital, Guri, Republic of Korea;Department of Pediatrics, Hanyang University Seoul Hospital, Seoul, Republic of Korea;Department of Pediatrics, Hanyang University Seoul Hospital, Seoul, Republic of Korea;Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Republic of Korea;

关键词: vitamin D deficiency;    vitamin D;    children;    adolescent;    administration and dosage;    treatment outcome;    safety;    retrospective studies;   

DOI  :  10.3389/fendo.2023.1265943

 received in 2023-07-24, accepted in 2023-10-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesWe aimed to evaluate the efficacy and safety of monthly vitamin D3 administration compared to a daily dosing regimen in healthy children with vitamin D deficiency.MethodsThis retrospective study included vitamin D deficient (serum 25-hydroxyvitamin D [25(OH)D] < 20 ng/mL) children with precocious puberty who received gonadotropin-releasing hormone agonist every 4 weeks between December 2019 and November 2022. We used propensity scores to 1:1 match daily (1,000 IU daily) and monthly (25,000 IU per 4 weeks) administration of vitamin D3 based on age, sex, body mass index Z-scores, season of blood collection, and baseline serum 25(OH)D concentrations.ResultsOf 299 children, 192 were matched based on propensity scores (126 girls and 66 boys, 10.5 ± 1.4years). After a mean follow-up of 5.9 months (standard deviation [SD] 2.5 months), the monthly group showed a statistically significant increase in serum 25(OH)D concentrations (10.9 ± 5.3 vs. 8.2 ± 7.2 ng/mL; p = 0.018), higher corrected dose-response (12.3 ± 5.9 vs. 8.2 ± 7.2 ng/mL increase per 1,000 IU daily; p = 0.002), and a higher proportion of patients attaining 25(OH)D > 20 ng/mL (78.1% vs. 58.3%,; p=0.005) compared with the daily group. No cases of hypercalcemia were observed in either group.ConclusionsMonthly administration of vitamin D3 may be an effective and safe alternative to correct hypovitaminosis D in pediatric population, possibly attributed to enhanced compliance.

【 授权许可】

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Copyright © 2023 Choi, Choe and Yang