Association of serum vitamin D concentration with the final course of hospitalization in patients with COVID-19

Frontiers in Immunology

Immunology

Barbara Adamik¹  Janusz Sokołowski²  Krzysztof Kaliszewski³  Michał Pomorski⁴  Adrian Doroszko⁵  Katarzyna Madziarska⁶  Katarzyna Kiliś-Pstrusińska⁷  Klaudia Konikowska⁸  Marcin Protasiewicz⁹  Ewa Anita Jankowska^1,10  Agnieszka Matera-Witkiewicz^1,11  Krzysztof Kujawa^1,12 

[1] Clinical Department of Anaesthesiology and Intensive Therapy, Wroclaw Medical University, Wroclaw, Poland;Clinical Department of Emergency Medicine, Wroclaw Medical University, Wroclaw, Poland;Clinical Department of General, Minimally Invasive and Endocrine Surgery, Wroclaw Medical University, Wroclaw, Poland;Clinical Department of Gynecology and Obstetrics, Wroclaw Medical University, Wroclaw, Poland;Clinical Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Wroclaw, Poland;Clinical Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland;Clinical Department of Paediatric Nephrology, Wroclaw Medical University, Wroclaw, Poland;Department of Dietetics and Bromatology, Wroclaw Medical University, Wroclaw, Poland;Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland;Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland;Institute of Heart Diseases, University Hospital, Wroclaw, Poland;Screening of Biological Activity Assays and Collection of Biological Material Laboratory, Wroclaw Medical University Biobank, Wroclaw Medical University, Wroclaw, Poland;Statistical Analysis Centre, Wroclaw Medical University, Wroclaw, Poland;

关键词: SARS-CoV-2;    vitamin D;    COVID-19;    mortality;    vitamin D deficiency;    public health;   

DOI  :  10.3389/fimmu.2023.1231813

 received in 2023-05-30, accepted in 2023-08-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundVitamin D deficiency is a substantial public health problem. The present study evaluated the association between vitamin D concentration and hospitalization and mortality risk in patients with coronavirus disease 19 (COVID-19).MethodsThis study used the COronavirus in LOwer Silesia (COLOS) dataset collected between February 2020 and June 2021. The medical records of 474 patients with confirmed severe acute respiratory syndrome 2 (SARS-CoV-2) infection, and whose vitamin D concentration was measured, were analyzed.ResultsWe determined a significant difference in vitamin D concentration between discharged patients and those who died during hospitalization (p = 0.0096). We also found an effect of vitamin D concentration on the risk of death in patients hospitalized due to COVID-19. As vitamin D concentration increased, the odds ratio (OR) for death slightly decreased (OR = 0.978; 95% confidence interval [CI] = 0.540-0.669). The vitamin D concentration cutoff point was 15.40 ng/ml. In addition, patients with COVID-19 and serum 25-hydroxyvitamin D (25(OH)D) concentrations < 30 ng/ml had a lower survival rate than those with serum 25(OH)D ≥ 30 ng/ml (log-rank test p = 0.0018). Moreover, a Cox regression model showed that patients with an estimated glomerular filtration rate (eGFR) ≥ 60 ml/min/1.73 m2 and higher vitamin D concentrations had a 2.8% reduced risk of mortality (hazard ratio HR = 0.972; CI = 0.95-0,99; p = 0.0097).ConclusionsThe results indicate an association between 25(OH)D levels in patients with COVID-19 and the final course of hospitalization and risk of death.

【 授权许可】

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Copyright © 2023 Konikowska, Kiliś-Pstrusińska, Matera-Witkiewicz, Kujawa, Adamik, Doroszko, Kaliszewski, Pomorski, Protasiewicz, Sokołowski, Madziarska and Jankowska