Demineralized dentin matrix promotes gingival healing in alveolar ridge preservation of premolars extracted for orthodontic reason: a split-mouth study

Frontiers in Endocrinology

Endocrinology

Kaijin Lin¹  Siyi Wang¹  Wei Zhao¹  Bowei Zhou¹  Xiaofeng Xu²  Dongsheng Peng³  Jin Yang⁴  Jianbin Guo⁴  Minqian Zheng⁴ 

[1] Fujian Provincial Engineering Research Center of Oral Biomaterial, Fujian Medical University, Fuzhou, China;School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China;Fujian Provincial Engineering Research Center of Oral Biomaterial, Fujian Medical University, Fuzhou, China;School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China;Department of Stomatology, Affiliated Hospital of Putian University, Putian, China;Fujian Provincial Engineering Research Center of Oral Biomaterial, Fujian Medical University, Fuzhou, China;School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China;Department of Stomatology, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China;Department of Stomatology, Fujian Obstetrics and Gynecology Hospital, Fuzhou, China;Fujian Provincial Engineering Research Center of Oral Biomaterial, Fujian Medical University, Fuzhou, China;School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China;Research Center of Dental and Craniofacial Implants, Fujian Medical University, Fuzhou, China;

关键词: demineralized dentin matrix;    alveolar ridge preservation;    gingival healing;    bone graft materials;    orthodontics;   

DOI  :  10.3389/fendo.2023.1281649

 received in 2023-08-22, accepted in 2023-10-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveThe purpose of this study was to prospectively evaluate the efficacy of a demineralized dentin matrix (DDM) in decreasing the initial inflammatory response of the gingiva and facilitating the repair and regeneration of soft tissue in alveolar ridge preservation.MethodsThis clinical study employed a split-mouth design. Fourteen patients with a total of forty-four sites underwent extraction and alveolar ridge preservation (ARP) procedures. A Bilaterally symmetrical extraction operation were conducted on the premolars of each patient. The experimental group received DDM as a graft material for ARP, while the control group underwent natural healing. Within the first month postoperatively, the pain condition, color, and swelling status of the extraction sites were initially assessed at different time points Subsequently, measurements were taken for buccal gingival margin height, buccal-lingual width, extraction socket contour, and the extraction socket area and healing rate were digitally measured. Additionally, Alcian Blue staining was used for histological evaluation of the content during alveolar socket healing.ResultsBoth groups experienced uneventful healing, with no adverse reactions observed at any of the extraction sites. The differences in VAS pain scores between the two groups postoperatively were not statistically significant. In the early stage of gingival tissue healing (3 days postoperatively), there were statistically significant differences in gingival condition and buccal gingival margin height between the two groups. In the later stage of gingival tissue healing (7, 14, and 30 days postoperatively), there were statistically significant differences in buccal-lingual width, extraction socket healing area, and healing rate between the two groups. Furthermore, the histological results from Alcian Blue staining suggested that the experimental group may play a significant role in promoting gingival tissue healing, possibly by regulating inflammatory responses when compared to the control group.ConclusionThe application of DDM in alveolar ridge preservation has been found to diminish initial gingival inflammation after tooth extraction. Additionally, it has shown the ability to accelerate early gingival soft tissue healing and preserve its anatomical contour.Clinical trial registrationchictr.org.cn, identifier ChiCTR2100050650.

【 授权许可】

Unknown   
Copyright © 2023 Xu, Peng, Zhou, Lin, Wang, Zhao, Zheng, Yang and Guo