Dual effects of radiotherapy on tumor microenvironment and its contribution towards the development of resistance to immunotherapy in gastrointestinal and thoracic cancers

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Margarita E. Neganova¹  Yulia Aleksandrova¹  Edmund Tse²  Olga A. Sukocheva²  Deyao Zhao³  Ruitai Fan³  Junqi Liu³  Yingyi Mo³  Vladimir N. Chubarev⁴ 

[1] Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia;Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Russia;Department of Hepatology, Royal Adelaide Hospital, CALHN, Adelaide, SA, Australia;Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia;

关键词: drug resistance;    radiotherapy;    tumor microenvironment;    angiogenesis;    cancer-associated fibroblasts;    exosome;    anti-cancer immunity;   

DOI  :  10.3389/fcell.2023.1266537

 received in 2023-07-25, accepted in 2023-09-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

Successful clinical methods for tumor elimination include a combination of surgical resection, radiotherapy, and chemotherapy. Radiotherapy is one of the crucial components of the cancer treatment regimens which allow to extend patient life expectancy. Current cutting-edge radiotherapy research is focused on the identification of methods that should increase cancer cell sensitivity to radiation and activate anti-cancer immunity mechanisms. Radiation treatment activates various cells of the tumor microenvironment (TME) and impacts tumor growth, angiogenesis, and anti-cancer immunity. Radiotherapy was shown to regulate signaling and anti-cancer functions of various TME immune and vasculature cell components, including tumor-associated macrophages, dendritic cells, endothelial cells, cancer-associated fibroblasts (CAFs), natural killers, and other T cell subsets. Dual effects of radiation, including metastasis-promoting effects and activation of oxidative stress, have been detected, suggesting that radiotherapy triggers heterogeneous targets. In this review, we critically discuss the activation of TME and angiogenesis during radiotherapy which is used to strengthen the effects of novel immunotherapy. Intracellular, genetic, and epigenetic mechanisms of signaling and clinical manipulations of immune responses and oxidative stress by radiotherapy are accented. Current findings indicate that radiotherapy should be considered as a supporting instrument for immunotherapy to limit the cancer-promoting effects of TME. To increase cancer-free survival rates, it is recommended to combine personalized radiation therapy methods with TME-targeting drugs, including immune checkpoint inhibitors.

【 授权许可】

Unknown   
Copyright © 2023 Zhao, Mo, Neganova, Aleksandrova, Tse, Chubarev, Fan, Sukocheva and Liu.