Transforming global approaches to chronic disease prevention and management across the lifespan: integrating genomics, behavior change, and digital health solutions

Frontiers in Public Health

Public Health

Marcia G. Ory¹  Samuel R. Chamberlain²  Britt Klein³  Fadi J Charchar³  Colette J Browning⁴  Henrietta Bowden-Jones⁵  Shane A Thomas⁶ 

[1] Center for Community Health and Aging, Texas A&M University, School of Public Health, College Station, TX, United States;Department of Psychiatry, Faculty of Medicine, University of Southampton, Southampton, United Kingdom;Southern Gambling Service, and Southern Health NHS Foundation Trust, Southampton, United Kingdom;Health Innovation and Transformation Centre (HITC), Federation University, Ballarat, VIC, Australia;Institute of Health and Wellbeing, Federation University, Ballarat, VIC, Australia;Health Innovation and Transformation Centre (HITC), Federation University, Ballarat, VIC, Australia;National Problem Gambling Clinic, London, United Kingdom;Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom;Faculty of Brain Sciences, University College London, London, United Kingdom;Vice Chancellor’s Office, Federation University, Ballarat, VIC, Australia;

关键词: chronic diseases;    prevention;    genomics;    risk prediction;    behavior change;    digital health;    healthy aging;   

DOI  :  10.3389/fpubh.2023.1248254

 received in 2023-06-26, accepted in 2023-09-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Chronic illnesses are a major threat to global population health through the lifespan into older age. Despite world-wide public health goals, there has been a steady increase in chronic and non-communicable diseases (e.g., cancer, cardiovascular and metabolic disorders) and strong growth in mental health disorders. In 2010, 67% of deaths worldwide were due to chronic diseases and this increased to 74% in 2019, with accelerated growth in the COVID-19 era and its aftermath. Aging and wellbeing across the lifespan are positively impacted by the presence of effective prevention and management of chronic illness that can enhance population health. This paper provides a short overview of the journey to this current situation followed by discussion of how we may better address what the World Health Organization has termed the “tsunami of chronic diseases.” In this paper we advocate for the development, validation, and subsequent deployment of integrated: 1. Polygenic and multifactorial risk prediction tools to screen for those at future risk of chronic disease and those with undiagnosed chronic disease. 2. Advanced preventive, behavior change and chronic disease management to maximize population health and wellbeing. 3. Digital health systems to support greater efficiencies in population-scale health prevention and intervention programs. It is argued that each of these actions individually has an emerging evidence base. However, there has been limited research to date concerning the combined population-level health effects of their integration. We outline the conceptual framework within which we are planning and currently conducting studies to investigate the effects of their integration.

【 授权许可】

Unknown   
Copyright © 2023 Thomas, Browning, Charchar, Klein, Ory, Bowden-Jones and Chamberlain.