期刊论文详细信息
Frontiers in Oncology
The relationship between cancer and biomechanics
Oncology
Lei Qin1  Hongru Kong2  Hongwei Sun2  Shengjie Dai3  Liqi Bao4  Yang Ja5  Chengchao Wang5 
[1] Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China;Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China;Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China;Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China;Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China;Renji College, Wenzhou Medical University, Wenzhou, Zhejiang, China;Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China;The First Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, China;
关键词: cancer;    biomechanics;    tumor microenvironment;    metastasis;    invasion;   
DOI  :  10.3389/fonc.2023.1273154
 received in 2023-08-08, accepted in 2023-09-27,  发布年份 2023
来源: Frontiers
PDF
【 摘 要 】

The onset, development, diagnosis, and treatment of cancer involve intricate interactions among various factors, spanning the realms of mechanics, physics, chemistry, and biology. Within our bodies, cells are subject to a variety of forces such as gravity, magnetism, tension, compression, shear stress, and biological static force/hydrostatic pressure. These forces are perceived by mechanoreceptors as mechanical signals, which are then transmitted to cells through a process known as mechanical transduction. During tumor development, invasion and metastasis, there are significant biomechanical influences on various aspects such as tumor angiogenesis, interactions between tumor cells and the extracellular matrix (ECM), interactions between tumor cells and other cells, and interactions between tumor cells and the circulatory system and vasculature. The tumor microenvironment comprises a complex interplay of cells, ECM and vasculature, with the ECM, comprising collagen, fibronectins, integrins, laminins and matrix metalloproteinases, acting as a critical mediator of mechanical properties and a key component within the mechanical signaling pathway. The vasculature exerts appropriate shear forces on tumor cells, enabling their escape from immune surveillance, facilitating their dissemination in the bloodstream, dictating the trajectory of circulating tumor cells (CTCs) and playing a pivotal role in regulating adhesion to the vessel wall. Tumor biomechanics plays a critical role in tumor progression and metastasis, as alterations in biomechanical properties throughout the malignant transformation process trigger a cascade of changes in cellular behavior and the tumor microenvironment, ultimately culminating in the malignant biological behavior of the tumor.

【 授权许可】

Unknown   
Copyright © 2023 Bao, Kong, Ja, Wang, Qin, Sun and Dai

【 预 览 】
附件列表
Files Size Format View
RO202311144683361ZK.pdf 962KB PDF download
  文献评价指标  
  下载次数:2次 浏览次数:1次