Inflammation-Induced Tumorigenesis and Metastasis

International Journal of Molecular Sciences

Mamiko Sakata-Yanagimoto¹  Koji Taniguchi²  Tetsuro Kawazoe²  Shinji Itoh³  Takatsugu Ishimoto⁴  Hidenori Kasahara⁵  Sana Hibino⁶ 

[1] Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan;Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan;Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan;Gastrointestinal Cancer Biology, International Research Center of Medical Sciences (IRCMS), Kumamoto University, Kumamoto 860-0811, Japan;National Center for Global Health and Medicine, Department of Stem Cell Biology, Research Institute, Tokyo 162-8655, Japan;Research Center for Advanced Science and Technology, Department of Inflammology, The University of Tokyo, Tokyo 153-0041, Japan;

关键词: inflammation;    cancer;    metastasis;    tumor microenvironment;    immunosuppression;   

DOI  :  10.3390/ijms22115421

来源: DOAJ

【 摘 要 】

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms and is now recognized as a hallmark of cancer and an attractive therapeutic target in cancer. In this review, we discuss recent advances in molecular mechanisms of how inflammation promotes tumorigenesis and metastasis and suppresses anti-tumor immunity in various types of solid tumors, including esophageal, gastric, colorectal, liver, and pancreatic cancer as well as hematopoietic malignancies.

【 授权许可】

Unknown