Albumins represent highly cross-reactive animal allergens

Frontiers in Immunology

Immunology

Zicheng Liu¹  Margarete Focke-Tejkl²  Inna Tulaeva³  Daria Trifonova³  Rudolf Valenta⁴  Alexander Karaulov⁵  Ksenja Riabova⁵  Evgeny Kozlov⁵  Antonina Karsonova⁵  Musa Khaitov⁶  Olga Elisyutina⁷  Ting-Huan Chen⁸ 

[1] Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria;Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria;Karl Landsteiner University of Healthcare, Krems, Austria;Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria;Laboratory for Immunopathology, Department of Clinical Immunology and Allergology, Sechenov First Moscow State Medical University, Moscow, Russia;Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria;Laboratory for Immunopathology, Department of Clinical Immunology and Allergology, Sechenov First Moscow State Medical University, Moscow, Russia;National Research Center, NRCI Institute of Immunology, Federal Medical-Biological Agency (FMBA) of Russia, Moscow, Russia;Karl Landsteiner University of Healthcare, Krems, Austria;Laboratory for Immunopathology, Department of Clinical Immunology and Allergology, Sechenov First Moscow State Medical University, Moscow, Russia;National Research Center, NRCI Institute of Immunology, Federal Medical-Biological Agency (FMBA) of Russia, Moscow, Russia;Pirogov Russian National Research Medical University, Moscow, Russia;National Research Center, NRCI Institute of Immunology, Federal Medical-Biological Agency (FMBA) of Russia, Moscow, Russia;RUDN University, Moscow, Russia;Worg Pharmaceuticals, Hangzhou, China;

关键词: allergy;    allergen;    epitope;    albumin;    cross-reactivity;    tolerance;    antibody;    immunoglobulin E (IgE);   

DOI  :  10.3389/fimmu.2023.1241518

 received in 2023-06-16, accepted in 2023-09-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

Albumins from animals are highly cross-reactive allergens for patients suffering from immunoglobulin E (IgE)-mediated allergy. Approximately 20-30% of cat and dog allergic patients show IgE reactivity and mount IgE-mediated allergic reactions to cat and dog albumin. It is astonishing that allergic patients can develop specific IgE responses against animal albumins because these proteins exhibit a more than 70% sequence identity to human serum albumin (HSA) which is the most abundant protein in the blood of the human body. The sequence identity of cat albumin (Fel d 2) and dog albumin (Can f 3) and HSA are 82% and 80%, respectively. Given the high degree of sequence identity between the latter two allergens and HSA one would expect that immunological tolerance would prohibit IgE sensitization to Fel d 2 and Can f 3. Here we discuss two possibilities for how IgE sensitization to Fel d 2 and Can f 3 may develop. One possibility is the failed development of immune tolerance in albumin-allergic patients whereas the other possibility is highly selective immune tolerance to HSA but not to Fel d 2 and Can f 3. If the first assumption is correct it should be possible to detect HSA-specific T cell responses and HSA-containing immune complexes in sensitized patients. In the latter scenario few differences in the sequences of Fel d 2 and Can f 3 as compared to HSA would be responsible for the development of selective T cell and B cell responses towards Fel d 2 as well as Can f 3. However, the immunological mechanisms of albumin sensitization have not yet been investigated in detail although this will be important for the development of allergen-specific prevention and allergen-specific immunotherapy (AIT) strategies for allergy to albumin.

【 授权许可】

Unknown   
Copyright © 2023 Liu, Trifonova, Tulaeva, Riabova, Karsonova, Kozlov, Elisyutina, Khaitov, Focke-Tejkl, Chen, Karaulov and Valenta