Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer

Frontiers in Immunology

Immunology

Tiarne van de Walle¹  Mohanraj Ramachandran¹  Anna Dimberg¹  Magnus Essand¹  Alessandra Vaccaro¹ 

[1] Department of Immunology, Genetics and Pathology, Science for Life Laboratory, The Rudbeck Laboratory, Uppsala University, Uppsala, Sweden;

关键词: tertiary lymphoid structures;    murine models;    cancer;    immunotherapy;    antigen-presenting niches;   

DOI  :  10.3389/fimmu.2023.1275378

 received in 2023-08-09, accepted in 2023-10-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

Tertiary lymphoid structures (TLS) are lymph node-like aggregates that can form in association with chronic inflammation or cancer. Mature TLS are organized into B and T cell zones, and are not encapsulated but include all cell types necessary for eliciting an adaptive immune response. TLS have been observed in various cancer types and are generally associated with a positive prognosis as well as increased sensitivity to cancer immunotherapy. However, a comprehensive understanding of the roles of TLS in eliciting anti-tumor immunity as well as the mechanisms involved in their formation and function is still lacking. Further studies in orthotopic, immunocompetent cancer models are necessary to evaluate the influence of TLS on cancer therapies, and to develop new treatments that promote their formation in cancer. Here, we review key insights obtained from functional murine studies, discuss appropriate models that can be used to study cancer-associated TLS, and suggest guidelines on how to identify TLS and distinguish them from other antigen-presenting niches.

【 授权许可】

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Copyright © 2023 Vaccaro, van de Walle, Ramachandran, Essand and Dimberg