Helicobacter pylori infection: a dynamic process from diagnosis to treatment

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Chengzhi Yuan¹  Xiong Cai²  Jing Lu³  Meiyan Zeng⁴  Houpan Song⁵  Qifang Sun⁵  Sainan Zhou⁶ 

[1] Hunan Provincial Key Laboratory of Traditional Chinese Medicine (TCM) Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan, China;School of Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China;School of International Education, Hunan University of Chinese Medicine, Changsha, Hunan, China;School of Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China;School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China;School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China;Hunan Provincial Key Laboratory of Traditional Chinese Medicine (TCM) Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan, China;The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China;

关键词: Helicobacter pylori;    pathogenesis;    diagnostic strategy;    treatment;    antibiotic resistance;   

DOI  :  10.3389/fcimb.2023.1257817

 received in 2023-07-13, accepted in 2023-10-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

Helicobacter pylori, a gram-negative microaerophilic pathogen, causes several upper gastrointestinal diseases, such as chronic gastritis, peptic ulcer disease, and gastric cancer. For the diseases listed above, H. pylori has different pathogenic mechanisms, including colonization and virulence factor expression. It is essential to make accurate diagnoses and provide patients with effective treatment to achieve positive clinical outcomes. Detection of H. pylori can be accomplished invasively and noninvasively, with both having advantages and limitations. To enhance therapeutic outcomes, novel therapeutic regimens, as well as adjunctive therapies with probiotics and traditional Chinese medicine, have been attempted along with traditional empiric treatments, such as triple and bismuth quadruple therapies. An H. pylori infection, however, is difficult to eradicate during treatment owing to bacterial resistance, and there is no commonly available preventive vaccine. The purpose of this review is to provide an overview of our understanding of H. pylori infections and to highlight current treatment and diagnostic options.

【 授权许可】

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Copyright © 2023 Sun, Yuan, Zhou, Lu, Zeng, Cai and Song