Case report: Successful treatment with contezolid in a patient with tuberculous meningitis who was intolerant to linezolid

Frontiers in Medicine

Medicine

Tingting Guan¹  Guichuan Wan¹  Linchuan Lang¹  Jing Zhang¹  Zhe Xu¹  Chao Jiang¹  Lianzhi Wang² 

[1] Harbin Chest Hospital, Harbin, Heilongjiang Province, China;null;

关键词: contezolid;    linezolid;    tuberculous meningitis;    case report;    antituberculosis drugs;   

DOI  :  10.3389/fmed.2023.1224179

 received in 2023-05-17, accepted in 2023-10-03,  发布年份 2023

来源: Frontiers

【 摘 要 】

Tuberculous meningitis (TBM) is the most common form of central nervous system tuberculosis (TB) and the most severe form of extrapulmonary TB. It often presents with non-specific symptoms initially and has a high mortality and disability rate. With good central nervous system penetration, linezolid is recommended for treating drug-resistant, severe, or refractory tuberculous meningitis in China. Despite the benefits of linezolid on TBM treatment, the adverse effects of long-term therapy, such as myelosuppression, peripheral neuritis, and optic neuritis, are notable and can be severe and even life-threatening, leading to discontinuation and compromising treatment expectations. Contezolid is a novel oxazolidinone antibacterial agent approved by the National Medical Products Administration of China in 2021, which has a more favorable safety profile than linezolid in terms of myelosuppression and monoamine oxidase inhibition. Here we first report a case of TBM in a patient who was intolerant to antituberculosis treatment with linezolid and achieved good efficacy and safety results after the compassionate use of contezolid. Given the widespread use of linezolid in TB treatment and the potential risks for long-term use, multi-center prospective controlled clinical trials in TB and TBM patients are needed to investigate the appropriate use of contezolid further.

【 授权许可】

Unknown   
Copyright © 2023 Xu, Zhang, Guan, Wan, Jiang, Lang and Wang.