Susceptibility to hypertension based on MTHFR rs1801133 single nucleotide polymorphism and MTHFR promoter methylation

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Chia-Hsiu Chang¹  Disline Manli Tantoh²  Yung-Po Liaw³  Chih-Hsuan Hsiao⁴  Ji-Han Zhong⁴  Ming-Huang Chiu⁵  Tsui-Wen Hsu⁶ 

[1] Cardiovascular Center, Cathay General Hospital, Taipei City, Taiwan;Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City, Taiwan;Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan;Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City, Taiwan;Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan;Institute of Medicine, Chung Shan Medical University, Taichung City, Taiwan;Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan;Department of Pulmonology and Respiratory Care, Cathay General Hospital, Taipei City, Taiwan;Superintendent Office, Institute of Medicine, Cathay General Hospital, Taipei City, Taiwan;

关键词: MTHFR;    promoter methylation;    rs1801133;    hypertension;    susceptibility;    interaction;   

DOI  :  10.3389/fcvm.2023.1159764

 received in 2023-02-07, accepted in 2023-09-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe aetio-pathologenesis of hypertension is multifactorial, encompassing genetic, epigenetic, and environmental factors. The combined effect of genetic and epigenetic changes on hypertension is not known. We evaluated the independent and interactive association of MTHFR rs1801133 single nucleotide polymorphism (SNP) and MTHFR promoter methylation with hypertension among Taiwanese adults.MethodsWe retrieved data including, MTHFR promoter methylation, MTHFR rs1801133 genotypes (CC, CT, and TT), basic demography, personal lifestyle habits, and disease history of 1,238 individuals from the Taiwan Biobank (TWB).ResultsThe distributions of hypertension and MTHFR promoter methylation quartiles (β < 0.1338, 0.1338 ≤ β < 0.1385, 0.1385 ≤ β < 0.1423, and β ≥ 0.1423 corresponding to

【 授权许可】

Unknown   
© 2023 Chiu, Chang, Tantoh, Hsu, Hsiao, Zhong and Liaw.