Associations of the MTHFR rs1801133 polymorphism with coronary artery disease and lipid levels: a systematic review and updated meta-analysis

Lipids in Health and Disease

Zhi Luo¹  Irfan Muhammad¹  Yun Chen¹  Zhan Lu¹  Yongyan Song²  Qiuhong Chen³  Jiaojiao Zhang³ 

[1] Department of Cardiology, Affiliated Hospital of North Sichuan Medical College;Department of Medical Biochemistry, School of Preclinical Medicine, North Sichuan Medical College;School of Clinical Medicine, North Sichuan Medical College;

关键词: 5,10-Methylenetetrahydrofolate reductase;    Polymorphism;    rs1801133;    Coronary artery disease;    Lipid;   

DOI  :  10.1186/s12944-018-0837-y

来源: DOAJ

【 摘 要 】

Abstract Background The associations of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) rs1801133 polymorphism with coronary artery disease (CAD) and plasma lipid levels have been widely investigated, but the results were inconsistent and inconclusive. This meta-analysis aimed to clarify the relationships of the rs1801133 polymorphism with CAD and plasma lipid levels. Methods By searching in PubMed, Google Scholar, Web of Science, Cochrane Library, Wanfang, VIP and CNKI databases, 123 studies (87,020 subjects) and 65 studies (85,554 subjects) were identified for the CAD association analysis and the lipid association analysis, respectively. Odds ratio (OR) and standardized mean difference (SMD) were used to determine the effects of the rs1801133 polymorphism on CAD risk and lipid levels, respectively. Results The variant T allele of the rs1801133 polymorphism was associated with increased risk of CAD under allelic model [OR = 1.11, 95% confidence interval (CI) = 1.06–1.17, P < 0.01], additive model (OR = 1.25, 95% CI = 1.14–1.37, P < 0.01), dominant model (OR = 1.11, 95% CI = 1.04–1.17, P < 0.01), and recessive model (OR = 1.22, 95% CI = 1.12–1.32, P < 0.01). The T carriers had higher levels of total cholesterol (TC) (SMD = 0.04, 95% CI = 0.01–0.07, P = 0.02) and low-density lipoprotein cholesterol (LDL-C) (SMD = 0.07, 95% CI = 0.01–0.12, P = 0.01) than the non-carriers. Conclusions The meta-analysis suggested that the T allele of the rs1801133 polymorphism is a risk factor for CAD, which is possibly and partly mediated by abnormal lipid levels.

【 授权许可】

Unknown