Unveiling the complexity: assessing models describing the structure and function of the nuclear pore complex

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Mark Tingey¹  Coby Rush¹  Fiona Feng¹  Zecheng Jiang¹  Weidong Yang² 

[1] Department of Biology, Temple University, Philadelphia, PA, United States;null;

关键词: nucleocytoplasmic transport;    super-resolution light microscopy;    nuclear pore complex;    transmembrane proteins;    intrinsically disordered protein;   

DOI  :  10.3389/fcell.2023.1245939

 received in 2023-06-24, accepted in 2023-09-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

The nuclear pore complex (NPC) serves as a pivotal subcellular structure, acting as a gateway that orchestrates nucleocytoplasmic transport through a selectively permeable barrier. Nucleoporins (Nups), particularly those containing phenylalanine–glycine (FG) motifs, play indispensable roles within this barrier. Recent advancements in technology have significantly deepened our understanding of the NPC's architecture and operational intricacies, owing to comprehensive investigations. Nevertheless, the conspicuous presence of intrinsically disordered regions within FG-Nups continues to present a formidable challenge to conventional static characterization techniques. Historically, a multitude of strategies have been employed to unravel the intricate organization and behavior of FG-Nups within the NPC. These endeavors have given rise to multiple models that strive to elucidate the structural layout and functional significance of FG-Nups. Within this exhaustive review, we present a comprehensive overview of these prominent models, underscoring their proposed dynamic and structural attributes, supported by pertinent research. Through a comparative analysis, we endeavor to shed light on the distinct characteristics and contributions inherent in each model. Simultaneously, it remains crucial to acknowledge the scarcity of unequivocal validation for any of these models, as substantiated by empirical evidence.

【 授权许可】

Unknown   
Copyright © 2023 Rush, Jiang, Tingey, Feng and Yang.